RT info:eu-repo/semantics/article
T1 Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study
A1 Jiménez Sousa, María Ángeles
A1 Engel López, Elisabeth
A1 Fernández Rodríguez, Amanda
A1 Tamayo Gómez, Eduardo
A1 Fernández Navarro, Pablo
A1 Segura Roda, Laura
A1 Heredia Rodríguez, María
A1 Gómez Herreras, José Ignacio
A1 Bustamante, Jesús
A1 García Gómez, Juan Miguel
A1 Bermejo Martín, Jesús Francisco
A1 Resino, Salvador
K1 Genetic polymorphism
K1 Polimorfismo genético
K1 Renal disease:
K1 Enfermedad renal
AB Background: Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem. Objective: To investigate whether single nucleotide polymorphisms (SNPs) located in genes related to immune and inflammatory processes, could be associated with ESRD development. Design and methods: A retrospective case-control study was carried out on 276 patients with ESRD and 288 control subjects. Forty-eight SNPs were genotyped via SNPlex platform. Logistic regression was used to assess the relationship between each sigle polymorphism and the development of ESRD. Results: Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). After adjusting for multiple testing, results lost significance. Conclusion: Our preliminary data suggest that four genetic polymorphisms located in genes related to inflammation and immune processes could help to predict the risk of developing ESRD.
PB Springer Nature
SN 1471-2350
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/45654
UL http://uvadoc.uva.es/handle/10324/45654
LA eng
NO BMC Medical Genetics, 2012, vol. 13. 6 p.
NO Producción Científica
DS UVaDOC
RD 04-dic-2024