RT info:eu-repo/semantics/article
T1 Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
A1 Cubero Gallego, Héctor
A1 Heredia Rodríguez, María
A1 Tamayo Gómez, Eduardo
K1 Cardiac troponin T
K1 Troponina T cardiaca
K1 Renal dysfunction
K1 Disfunción renal
K1 Myocardial infarction
K1 Infarto de miocardio
K1 3213.07 Cirugía del Corazón
AB We aimed to assess the influence of impairment in renal function over the high-sensitivity cardiac troponin T (hs-cTnT) accuracy to diagnose perioperative myocardial infarction (MI) after heart valve surgery. Heart valve surgery was performed in 805 patients from June 2012 to January 2016. Patients with enzymatic curves of hs-cTnT suggestive of myocardial necrosis and electrocardiogram and/or transthoracic echocardiogram criteria were identified as patients with perioperative MI. Impairment in renal function was defined as a postoperative creatinine clearance <50 ml/min at 16 h after surgery and for at least 48 h. Patients included were divided into 2 groups at 16 h: (i) patients with normal renal function (creatinine clearance >50 ml/min) and (ii) patients with impairment in renal function (creatinine clearance <50 ml/min). From a total of 805 patients undergoing heart valve surgery, 88 patients developed perioperative MI. When comparing receiver operating characteristic curves in patients with perioperative MI according to renal function, the optimal threshold of hs-cTnT at 16 h differed in patients with impairment in renal function (1303 vs 1095 pg/ml, P < 0.001). The diagnostic accuracy of hs-cTnT at 16 h was 93.4% [95% confidence interval (CI) 89.98–96.86], with an area under receiver operating characteristic curve (0.993, 95% CI 0.988–0.999 vs 0.972, 95% CI 0.952–0.992; P < 0.001). Renal function might influence in hs-cTnT levels. However, a hs-cTnT threshold of 1303 pg/ml at 16 h may be applied according to renal function to diagnose perioperative MI after cardiac surgery.
PB Oxford University Press
SN 1569-9285
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/45726
UL http://uvadoc.uva.es/handle/10324/45726
LA eng
NO Interactive CardioVascular and Thoracic Surgery, 2018, vol. 27, n. 2. p. 234–237
NO Producción Científica
DS UVaDOC
RD 03-dic-2024