RT info:eu-repo/semantics/article
T1 Epidemiological trends of sepsis in the twenty-first century (2000–2013): an analysis of incidence, mortality, and associated costs in Spain
A1 Álvaro Meca, Alejandro
A1 Jiménez Sousa, María Ángeles
A1 Micheloud, Dariela
A1 Sánchez Lopez, Ainhoa
A1 Heredia Rodríguez, María
A1 Tamayo Gómez, Eduardo
A1 Resino, Salvador
K1 Sepsis
K1 Mortality
K1 Mortalidad
K1 Epidemiology
K1 Epidemiología
AB Background: Sepsis has represented a substantial health care and economic burden worldwide during the previous several decades. Our aim was to analyze the epidemiological trends of hospital admissions, deaths, hospital resource expenditures, and associated costs related to sepsis during the twenty-first century in Spain. Methods: We performed a retrospective study of all sepsis-related hospitalizations in Spanish public hospitals from 2000 to 2013. Data were obtained from records in the Minimum Basic Data Set. The outcome variables were sepsis, death, length of hospital stay (LOHS), and sepsis-associated costs. The study period was divided into three calendar periods (2000–2004, 2005–2009, and 2010–2013). Results: Overall, 2,646,445 patients with sepsis were included, 485,685 of whom had died (18.4%). The incidence of sepsis (events per 1000 population) increased from 3.30 (2000–2004) to 4.28 (2005–2009) to 4.45 (2010–2013) (p < 0.001). The mortality rates from sepsis (deaths per 10,000 population) increased from 6.34 (2000–2004) to 7.88 (2005–2009) to 7.89 (2010–2013) (p < 0.001). The case fatality rate (CFR) or proportion of patients with sepsis who died decreased from 19.1% (2000–2004) to 18.4% (2005–2009) to 17.9% (2010–2013) (p < 0.001). The LOHS (days) decreased from 15.9 (2000–2004) to 15.7 (2005–2009) to 14.5 (2010–2013) (p < 0.001). Total and per patient hospital costs increased from 2000 to 2011, and then decreased by the impact of the economic crisis. Conclusions: Sepsis has caused an increasing burden in terms of hospital admission, deaths, and costs in the Spanish public health system during the twenty-first century, but the incidence and mortality seemed to stabilize in 2010–2013. Moreover, there was a significant decrease in LOHS in 2010–2013 and a decline in hospital costs after 2011.
PB Springer Nature
SN 1478-7954
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/45731
UL http://uvadoc.uva.es/handle/10324/45731
LA eng
NO Population Health Metrics, 2018, vol. 16. 11 p.
NO Producción Científica
DS UVaDOC
RD 06-ago-2024