RT info:eu-repo/semantics/article
T1 Embryonic cerebrospinal fluid regulates neuroepithelial survival proliferation and neurogenesis in chick embryos
A1 Gato Casado, Ángel Luis
A1 Moro Balbás, José Antonio
A1 Alonso Revuelta, María Isabel
A1 Bueno i Torrens, David
A1 Mano Bonín, Anibal de la
K1 Embriología
K1 Líquido cefalorraquídeo
K1 Neurología
AB Early in development, the  behavior of neuroepithelial cells is controlled by several factors, which  act  in  a developmentally regulated manner. Dif- fusible factors are  secreted locally  by the  neuroepithelium itself, although other nearby structures may  also  be involved. Evidence suggests a physio- logical role for the  cerebrospinal fluid  in the  development of the  brain. Here, using organotypic cultures of chick  embryo neuroepithelial explants from the  mesencephalon, we show that the  neuroepithelium in vitro  is not able to self-induce cell survival, replication, and  neurogenesis. We also  show  that the  embryonic cerebrospinal fluid  (E-CSF) promotes neuroepithelial stem cell survival and  induces proliferation and  neurogenesis in  mesencephalic explants. These data strongly suggest that E-CSF is involved in the  regu- lation of neuroepithelial cells behavior, supporting the  hypothesis that this fluid  plays a key  role  during the  early development of the  central nervous system.
PB Wiley-Liss
SN 003-276X
YR 2005
FD 2005
LK http://uvadoc.uva.es/handle/10324/4574
UL http://uvadoc.uva.es/handle/10324/4574
LA eng
NO The Anatomical record. Part A, 2005, p. 475-484
NO Producción Científica
DS UVaDOC
RD 23-nov-2024