RT info:eu-repo/semantics/article
T1 HIV-2 viral tropism influences CD4+ T cell count regardless of viral load
A1 Treviño, Ana
A1 Soriano, Vincent
A1 Poveda, Eva
A1 Parra, Patricia
A1 Cabezas, Teresa
A1 Caballero, Estrella
A1 Roc, Lourdes
A1 Rodríguez, Carmen
A1 Eiros Bouza, José María
A1 López, Mariola
A1 Mendoza, Carmen de
K1 Antagonistas
K1 Carga proviral
K1 Maraviroc
K1 32 Ciencias Médicas
AB Background:HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in compari-son with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails toprovide optimal CD4 recovery.Methods:We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viraltropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA.Results:From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%).Patients with X4 viruses had lower median CD4+cell counts than patients with R5 viruses [130 (17 – 210) versus359 (180 – 470) cells/mm3;P¼0.007]. This was true even considering only the subset of 19 patients on antiretro-viral therapy [94 (16 – 147) versus 184 (43 – 368) cells/mm3;P¼0.041]. In multivariate analysis, significant differ-ences in CD4+cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender,antiretroviral therapy and viral load.Conclusions:The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+cell counts, regard-less of antiretroviral treatment. Along with CD4+cell counts, viral tropism testing may assist decisions aboutwhen to initiate antiretroviral therapy in HIV-2-infected individuals.
PB Oxford University Press
SN 0305-7453
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/45935
UL http://uvadoc.uva.es/handle/10324/45935
LA eng
NO Journal of Antimicrobial Chemotherapy, 2014, vol. 69, n. 8, p. 2191-2194
NO Producción Científica
DS UVaDOC
RD 22-dic-2024