RT info:eu-repo/semantics/article T1 HIV-2 viral tropism influences CD4+ T cell count regardless of viral load A1 Treviño, Ana A1 Soriano, Vincent A1 Poveda, Eva A1 Parra, Patricia A1 Cabezas, Teresa A1 Caballero, Estrella A1 Roc, Lourdes A1 Rodríguez, Carmen A1 Eiros Bouza, José María A1 López, Mariola A1 Mendoza, Carmen de K1 Antagonistas K1 Carga proviral K1 Maraviroc K1 32 Ciencias Médicas AB Background:HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in compari-son with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails toprovide optimal CD4 recovery.Methods:We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viraltropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA.Results:From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%).Patients with X4 viruses had lower median CD4+cell counts than patients with R5 viruses [130 (17 – 210) versus359 (180 – 470) cells/mm3;P¼0.007]. This was true even considering only the subset of 19 patients on antiretro-viral therapy [94 (16 – 147) versus 184 (43 – 368) cells/mm3;P¼0.041]. In multivariate analysis, significant differ-ences in CD4+cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender,antiretroviral therapy and viral load.Conclusions:The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+cell counts, regard-less of antiretroviral treatment. Along with CD4+cell counts, viral tropism testing may assist decisions aboutwhen to initiate antiretroviral therapy in HIV-2-infected individuals. PB Oxford University Press SN 0305-7453 YR 2014 FD 2014 LK http://uvadoc.uva.es/handle/10324/45935 UL http://uvadoc.uva.es/handle/10324/45935 LA eng NO Journal of Antimicrobial Chemotherapy, 2014, vol. 69, n. 8, p. 2191-2194 NO Producción Científica DS UVaDOC RD 04-oct-2024