RT info:eu-repo/semantics/article
T1 Early embryonic brain development in rats requieres the trophic influence of cerebrospinal fluid
A1 Martín, C.
A1 Alonso Revuelta, María Isabel
A1 Santiago, C.
A1 Moro Balbás, José Antonio
A1 Mano Bonín, Anibal de la
A1 Carretero Soto, Raquel
A1 Gato Casado, Ángel Luis
K1 Tubo neural
K1 Embriología
K1 Neurogénesis
AB Particularly evCerebrospinal fluid has shown itself to be  an essential brain component during development. This  is parident at the earliest stages of development where a lot  of research, performed mainly in chick embryos, supports the evidence that  cerebrospinal fluid is  involved in  different mechanisms controlling brain growth and morphogenesis, by  exerting a trophic effect on  neuroepithelial precursor cells (NPC) involved in controlling the behaviour of these cells. Despite it being known that cerebrospinal fluid in mammals is directly involved in corticogenesis at fetal stages, the influence of cerebrospinal fluid on the activity of NPC at the earliest stages of brain development has not been demonstrated. Here, using‘‘in vitro’’ organotypic cultures of rat embryo brain neuroepithelium in order to expose NPC to or deprive them of  cerebrospinal fluid, we  show that the neuroepithelium needs the trophic influence of cerebrospinal fluid to undergo normal rates of cell survival, replication and neurogenesis, suggesting that NPC are not self-sufficient to induce their normal activity. This  data shows that cerebrospinal fluid is an essential component in  chick and rat early brain development, suggesting that its influence could be constant in higher vertebrates.
PB Elsevier
SN 0736-5748
YR 2009
FD 2009
LK http://uvadoc.uva.es/handle/10324/4620
UL http://uvadoc.uva.es/handle/10324/4620
LA eng
NO International Journal of Developmental Neuroscience, 2009, vol. 27. p. 733-740
NO Producción Científica
DS UVaDOC
RD 22-dic-2024