RT info:eu-repo/semantics/article
T1 Role of interleukin 1B in the control of neuropithelial proliferation and differentiation of the spinal cord during development
A1 Mano Bonín, Anibal de la
A1 Gato Casado, Ángel Luis
A1 Alonso Revuelta, María Isabel
A1 Carnicero Gila, Estela María
A1 Martín, C.
A1 Moro Balbás, José Antonio
K1 Embriología
K1 Nervioso, Sistema - Enfermedades
AB Interleukin-1b (IL-1b) is an important trophic factor in the nervous system (NS). IL-1b  is ubiquitously  expressed from very early stages during the development of the amphibian NS and its action has been demonstrated in vitro on survival, proliferation and differ- entiation in mammalian embryos. In this report, we show that IL-1b is immunocytochemically  expressed in embryonic spinal cord from early stages, both in rat (embryonic day 12) and in chicken (stage 17-HH), in neuroepithelial cells and nerve fibres, dorsal root ganglia, anterior and posterior roots of the spinal nerves, and in the fibres of these nerves. Our in vivo experiments on chick embryos, with micro- beads impregnated with IL-1b implanted laterally to the spinal cord at the level of the wing anlage, demonstrate that this cytokine pro- duces a statistically significant increase in nuclear incorporation of BrdU at the dorsal level and a reduction of this at the ventral level, whereas local immunoblocking  with anti-IL-1b antibodies causes a dorsal reduction of BrdU incorporation and alters ventral differen- tiation. These data demonstrate that IL-1b plays a part in controlling proliferation and early differentiation during the development of the spinal cord in chick embryos.
PB Elsevier
SN 1043-4666
YR 2007
FD 2007
LK http://uvadoc.uva.es/handle/10324/4632
UL http://uvadoc.uva.es/handle/10324/4632
LA eng
NO Citokine, vol. 37. p.128-137
NO Producción Científica
DS UVaDOC
RD 16-abr-2024