RT info:eu-repo/semantics/article
T1 Voltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materials
A1 Fischer, Jan
A1 González Martín, Javier
A1 Lochyński, Paweł
A1 Dejmková, Hana
A1 Schwarzová Pecková, Karolina
A1 Vega, Marisol
K1 Voltamétrico
K1 Terconazol
K1 23 Química
K1 24 Ciencias de la Vida
AB Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in its molecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L−1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 μmol L−1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD ~ 4%) and detection limits reaching 0.50 μmol L−1 and 1.23 μmol L−1, respectively.
PB Elsevier
SN 1572-6657
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/46746
UL https://uvadoc.uva.es/handle/10324/46746
LA eng
NO Journal of Electroanalytical Chemistry, 2020, vol. 863, p. 114054
NO Producción Científica
DS UVaDOC
RD 12-nov-2024