RT info:eu-repo/semantics/article
T1 Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia
A1 Prieto Lloret, Jesús
A1 Ramírez Arroyo, María
A1 Olea Fraile, Elena
A1 Moral Sanz, Javier
A1 Cogolludo Torralba, Ángel
A1 Castañeda, Javier
A1 Yubero Benito, Sara
A1 Agapito Serrano, María Teresa
A1 Gómez Niño, María Ángeles
A1 Rocher Martín, María Asunción
A1 Rigual Bonastre, Ricardo Jaime
A1 Obeso Cáceres, Ana María de la Luz
A1 Pérez Vizcaíno, Francisco
A1 González, Constancio
K1 Hypoxia
K1 Hipoxia
K1 Vasoconstriction
K1 Vasoconstricción
K1 Carotid body
K1 Cuerpo carotídeo
K1 Erythropoietin
K1 Eritropoyetina
AB Adult mammalians possess three cell systems that are activated by acute bodily hypoxia: pulmonary artery smooth muscle cells (PASMC), carotid body chemoreceptor cells (CBCC) and erythropoietin (EPO)-producing cells. In rats, chronic perinatal hyperoxia causes permanent carotid body (CB) atrophy and functional alterations of surviving CBCC. There are no studies on PASMC or EPO-producing cells. Our aim is to define possible long-lasting functional changes in PASMC or EPO-producing cells (measured as EPO plasma levels) and, further, to analyse CBCC functional alterations. We used 3- to 4-month-old rats born and reared in a normal atmosphere or exposed to perinatal hyperoxia (55–60% O2 for the last 5–6 days of pregnancy and 4 weeks after birth). Perinatal hyperoxia causes an almost complete loss of hypoxic pulmonary vasoconstriction (HPV), which was correlated with lung oxidative status in early postnatal life and prevented by antioxidant supplementation in the diet. O2-sensitivity of K+ currents in the PASMC of hyperoxic animals is normal, indicating that their inhibition is not sufficient to trigger HPV. Perinatal hyperoxia also abrogated responses elicited by hypoxia on catecholamine and cAMP metabolism in the CB. An increase in EPO plasma levels elicited by hypoxia was identical in hyperoxic and control animals, implying a normal functioning of EPO-producing cells. The loss of HPV observed in adult rats and caused by perinatal hyperoxia, comparable to oxygen therapy in premature infants, might represent a previously unrecognized complication of such a medical intervention capable of aggravating medical conditions such as regional pneumonias, atelectases or general anaesthesia in adult life.
PB The Physiological Society
SN 1469-7793
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/46966
UL https://uvadoc.uva.es/handle/10324/46966
LA eng
NO The Journal of Physiology, 2015, vol. 593, n. 11. p. 2459-2477
NO Producción Científica
DS UVaDOC
RD 24-abr-2024