RT info:eu-repo/semantics/article
T1 The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling
A1 Puerta Turrillas, María Luisa de la
A1 Trinidad, Antonio G.
A1 Rodríguez, María del Carmen
A1 Pereda, José María de
A1 Sánchez Crespo, Mariano
A1 Bayón Prieto, Yolanda
A1 Alonso, Andrés
K1 Autoinmunidad
K1 Proteína tirosina fosfatasa
K1 24 Ciencias de la Vida
AB The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. This polymorphism changes an R by a W in the P1 Pro rich motif of LYP, which binds to CSK SH3 domain, another negative regulator of TCR signaling. Based on the analysis of the mouse homologue, Pep, it was proposed that LYP and CSK bind constitutively to inhibit LCK and subsequently TCR signaling. The detailed study of LYP/CSK interaction, here presented, showed that LYP/CSK interaction was inducible upon TCR stimulation, and involved LYP P1 and P2 motifs, and CSK SH3 and SH2 domains. Abrogating LYP/CSK interaction did not preclude the regulation of TCR signaling by these proteins.
PB Public Library of Science
SN 1932-6203
YR 2013
FD 2013
LK https://uvadoc.uva.es/handle/10324/47495
UL https://uvadoc.uva.es/handle/10324/47495
LA eng
NO PLoS ONE, 2013, vol. 8, n. 1, p. e54569
NO Producción Científica
DS UVaDOC
RD 23-abr-2024