RT info:eu-repo/semantics/article
T1 Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
A1 López Urrutia, Luis
A1 Alonso, Andrés
A1 Nieto, Maria Luisa
A1 Bayón Prieto, Yolanda
A1 Orduña Domingo, Antonio
A1 Sánchez Crespo, Mariano
K1 Lipopolisacáridos
K1 Lipopolysaccharides
K1 Brucella abortus
K1 Brucella melitensis
K1 Macrófagos
K1 Macrophages
K1 24 Ciencias de la Vida
AB Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced theproduction of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of productionof NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) wasconfirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observationsmight help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septicshock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans.
PB American Society for Microbiology
SN 0019-9567
YR 2000
FD 2000
LK https://uvadoc.uva.es/handle/10324/47499
UL https://uvadoc.uva.es/handle/10324/47499
LA eng
NO Infection and Immunity, 2000, vol 68, n. 3, p. 1740-1745
NO Producción Científica
DS UVaDOC
RD 12-sep-2024