RT info:eu-repo/semantics/article
T1 Cerebroespinal fluid control of neurogenesis induced by retinoic acid during early brain development
A1 Alonso Revuelta, María Isabel
A1 Martín, C.
A1 Carnicero Gila, Estela María
A1 Bueno i Torrens, David
A1 Gato Casado, Ángel Luis
K1 Neurología del desarrollo
AB Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the controlof neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shownto be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF containsall-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesisinducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able tosynthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesisin the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity,which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonicbrain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help tounderstand neurogenesis from neural progenitor cells
PB Wiley
SN 1058-8388
YR 2011
FD 2011
LK http://uvadoc.uva.es/handle/10324/4884
UL http://uvadoc.uva.es/handle/10324/4884
LA eng
NO Developmental Dynamics, 2011
NO Producción Científica
DS UVaDOC
RD 11-dic-2024