RT info:eu-repo/semantics/article T1 Cerebroespinal fluid control of neurogenesis induced by retinoic acid during early brain development A1 Alonso Revuelta, María Isabel A1 Martín, C. A1 Carnicero Gila, Estela María A1 Bueno i Torrens, David A1 Gato Casado, Ángel Luis K1 Neurología del desarrollo AB Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the controlof neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shownto be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF containsall-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesisinducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able tosynthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesisin the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity,which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonicbrain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help tounderstand neurogenesis from neural progenitor cells PB Wiley SN 1058-8388 YR 2011 FD 2011 LK http://uvadoc.uva.es/handle/10324/4884 UL http://uvadoc.uva.es/handle/10324/4884 LA eng NO Developmental Dynamics, 2011 NO Producción Científica DS UVaDOC RD 29-mar-2024