RT info:eu-repo/semantics/article
T1 Unexpected domino Silyl-Prins/Aryl migration process from geminal Vinylsilyl alcohols
A1 Díez Poza, Carlos
A1 Barbero Pérez, María Asunción
K1 Alcohols
K1 Alcoholes
K1 Aldehydes
K1 Aldehídos
K1 Genetics
K1 Genética
K1 Cyclization
K1 Ciclización
AB The silyl-Prins cyclization of geminal vinylsilyl alcohols and aldehydes, promoted by TMSOTf, provides access to polysubstituted tetrahydropyrans in which the silyl group remains in the molecule and an aryl group has migrated from silicon to carbon. This domino silyl-Prins/aryl migration process is general and high-yielding for aryl, vinyl, or alkyl aldehydes. Moreover, cyclization proceeds with very high stereocontrol in a one-pot reaction in which both quaternary and tertiary stereogenic centers have been created.
PB ACS Publications
SN 1523-7060
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/49782
UL https://uvadoc.uva.es/handle/10324/49782
LA eng
NO Organic Letters, 2021, vol. 23, n. 21. p. 8385-8389
NO Producción Científica
DS UVaDOC
RD 28-nov-2024