RT info:eu-repo/semantics/article
T1 Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
A1 Coca Rojo, Armando
A1 Arias Cabrales, Carlos Enrique
A1 Valencia Peláez, Ana Lucía
A1 Burballa Tarrega, Carla Cristina
A1 Bustamante Munguira, Juan
A1 Redondo Pachón, María Dolores
A1 Acosta Ochoa, María Isabel
A1 Crespo Barrio, Marta
A1 Bustamante Bustamante, Jesús
A1 Mendiluce Herrero, Alicia
A1 Pascual Santos, Julio
A1 Pérez Saéz, María José
K1 Riñones - Enfermedades - Tratamiento
K1 Riñones - Trasplante
K1 Survival
K1 Supervivencia
K1 3205.06 Nefrología
AB Pre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organdiscard rates. Since most of these scores come from the US, direct application in non-US populations isnot advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival(EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed toexamine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohortbased study of deceased-donor kidney transplants carried out in two different Spanish hospitals.Unadjusted and adjusted Cox models were applied for patient survival. Predictive models werecompared using Harrell’s C statistics. SBE, EPTS and KDPI were independently associated with patientsurvival (p ≤ 0.01 in all models). Model discrimination measured with Harrell’s C statistics ranged from0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration anddiscrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly amonghigh EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating posttransplantsurvival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing.
PB Springer
SN 2045-2322
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/50759
UL https://uvadoc.uva.es/handle/10324/50759
LA eng
NO Scientific Reports, 2020, vol. 10, 17109
NO Producción Científica
DS UVaDOC
RD 22-nov-2024