RT info:eu-repo/semantics/article
T1 Hypoglycemia following intravenous insulin plus glucose for hyperkalemia in patients with impaired renal function
A1 Coca Rojo, Armando
A1 Valencia Peláez, Ana Lucía
A1 Bustamante Bustamante, Jesús
A1 Mendiluce Herrero, Alicia
A1 Floege, Jürgen
K1 Hipoglucemia
K1 Insuficiencia renal
K1 Insulina
K1 Riñones - Enfermedades
K1 3205.06 Nefrología
AB Background: Hypoglycemia is a serious complication following the administration of insulin for hyperkalemia. We determined the incidence of hypoglycemia and severe hypoglycemia (blood glucose <70 or ≤40 mg/dl, respectively) in a cohort of AKI and non-dialysis dependent CKD patients who received an intravenous infusion of insulin plus glucose to treat hyperkalemia. Methods: We retrospectively reviewed charts of all AKI and non-dialysis dependent CKD patients who received 10 U of insulin plus 50 g glucose to treat hyperkalemia from December 1, 2013 to May 31, 2015 at our Department.  Results: One hundred sixty four episodes of hyperkalemia were treated with insulin plus glucose and were eligible for analysis. Serum potassium levels dropped by 1.18 ± 1.01 mmol/l. Eleven treatments (6.1%) resulted in hypoglycemia and two (1.2%) in severe hypoglycemia. A lower pretreatment blood glucose tended to associate with a higher subsequent risk of hypoglycemia. Age, sex, renal function, an established diagnosis of diabetes or previous treatment were not associated with the development of this complication. We did not register any significant adverse events. Conclusion: Our intravenous regimen combining an infusion of insulin plus glucose effectively reduced serum potassium levels compared to previous studies and associated a low risk of symptomatic hypoglycemia and other complications.
PB Public Library of Science
SN 1932-6203
YR 2017
FD 2017
LK https://uvadoc.uva.es/handle/10324/50764
UL https://uvadoc.uva.es/handle/10324/50764
LA eng
NO PLoS ONE, 2017, vol. 12, n. 2
NO Producción Científica
DS UVaDOC
RD 09-may-2024