RT info:eu-repo/semantics/article
T1 Heterogeneity of induction therapy in Spain: changing patterns according to year, centre, indications and results
A1 Rodrigo Calabia, Emilio
A1 Fernandez Fresnedo, Gema
A1 Robledo Zulet, Carmen
A1 Palomar Fontanet, Rosa
A1 Cantarell Aixandri, María del Carmen
A1 Mazuecos Blanca, Auxiliadora
A1 Osuna Ortega, Antonio
A1 Mendiluce Herrero, Alicia
A1 Alarcón Zurita, Antonio
A1 Arias Rodríguez, Manuel
K1 Riñones - Trasplante
K1 Riñones - Enfermedades - Tratamiento
K1 Induction therapy
K1 3205.06 Nefrología
AB Background. The use of induction drugs has increased markedly over the last 15 years in the USA, but there are few data about their use in other countries. Moreover, there are not enough data about when they are indicated and their long-term effects. The aim of our study was to know the rates of use and the drugs used as induction therapy, in which patients they were prescribed and the long-term graft survival effect in Spain. Methods. We conducted a retrospective cohort study with adult patients (4861) receiving a kidney allograft in Spain over four different years (1990, 1994, 1998 and 2002) with a functioning graft at the end of the first post-transplant year. Induction therapy was defined as when the patient received polyclonal antibodies, OKT3 monoclonal antibodies or anti-CD25 monoclonal antibodies. Results. From 1990 to 2002, the use of induction therapy in Spain changed, with a progressive reduction in the use of OKT3 and an increasing use of anti-CD25 antibodies. There were great differences in the rate of induction use from one centre to another, although with a common trend to greater use at each centre. Induction therapy was mainly prescribed in patients with a higher rejection risk (higher panel reactive antibody (PRA) titres and mismatches and re-transplants) and in older and diabetic recipients. Lastly, patients who were treated with induction therapy had significant higher allograft survival than those who did not (P value = 0.035). Conclusions. The use of induction therapy in Spain has changed, with an increasing use of monoclonal antibodies in recent years. Induction therapy has a protective role in long-term graft survival.
PB Oxford University Press
SN 1753-0784
YR 2010
FD 2010
LK https://uvadoc.uva.es/handle/10324/50768
UL https://uvadoc.uva.es/handle/10324/50768
LA eng
NO NDT Plus, 2010, vol. 3, supl. 2, p. 9-14
NO Producción Científica
DS UVaDOC
RD 26-nov-2024