RT info:eu-repo/semantics/article
T1 Recipient age as a determinant factor of patient and graft survival
A1 Moreso Mateos, Francesc
A1 Ortega Suárez, Francisco
A1 Mendiluce Herrero, Alicia
K1 Riñones - Trasplante
K1 Survival
K1 Supervivencia
K1 3205.06 Nefrología
AB Background. Age of renal transplants has been related to death, alloimmune response and graft outcome. We reviewed the influence of patient age on transplant outcome in three cohorts of patients transplanted in Spain during the 1990s. Methods. Patient age was categorized into four groups (I, 18–40; II, 41–50; III, 51–60; and IV, > 60 years). Risks factors for acute rejection were evaluated by logistic regression adjusting for transplant centre and transplantation year, while a Cox proportional hazard model was employed for analysing patient and graft survival. Results. Older patients had a higher death rate (I, 3.5%; II, 7.7%; III, 13.2%; and IV, 16.9%; P<0.001), but a lower standardized mortality index (I, 7.6; II, 7.0; III, 5.8; and IV, 4.1; P = 0.0019). Older patients had the lowest risk of acute rejection [odds ratio (OR) 0.79 and 95% confidence interval (CI) 0.66–0.97 for group II; OR 0.75 and 95% CI 0.62–0.91 for group III; OR 0.43 and 95% CI 0.33–0.56 for group IV). Death-censored graft survival was poorer in patients older than 60 years (relative risk 1.40; 95% CI 1.09–1.80), but this result was not explained by any combination of patient age with donor age, delayed graft function or immunosuppression. Conclusions. Patient age is a main determinant of transplant outcome. Although death rate is higher for older patients, standardized mortality was not. Thus, the efforts to reduce mortality should be also implemented in younger patients. Old patients have a low risk of acute rejection but a poorer death-censored graft survival. This last result was not explained by any controlled variable in our study.
PB Oxford University Press
SN 0931-0509
YR 2004
FD 2004
LK https://uvadoc.uva.es/handle/10324/50769
UL https://uvadoc.uva.es/handle/10324/50769
LA eng
NO Nephrology Dialysis Transplantation, 2004, vol. 19, supl. 3, p. 16–20
NO Producción Científica
DS UVaDOC
RD 22-nov-2024