RT info:eu-repo/semantics/article
T1 Impact on outcomes across KDIGO-2012 AKI criteria according to baseline renal function
A1 Acosta Ochoa, María Isabel
A1 Bustamante Munguira, Juan
A1 Mendiluce Herrero, Alicia
A1 Bustamante Bustamante, Jesús
A1 Coca Rojo, Armando
K1 Riñones - Enfermedades
K1 Chronic renal failure
K1 Insuficiencia renal crónica
K1 3205.06 Nefrología
AB Acute kidney injury (AKI) and Chronic Kidney Disease (CKD) are global health problems. The pathophysiology of acute-on-chronic kidney disease (AoCKD) is not well understood. We aimed to study clinical outcomes in patients with previous normal (pure acute kidney injury; P-AKI) or impaired kidney function (AoCKD) across the 2012 Kidney Disease Improving Global Outcomes (KDIGO) AKI classification. We performed a retrospective study of patients with AKI, divided into P-AKI and AoCKD groups, evaluating clinical and epidemiological features, distribution across KDIGO-2012 criteria, in-hospital mortality and need for dialysis. One thousand, two hundred and sixty-nine subjects were included. AoCKD individuals were older and had higher comorbidity. P-AKI individuals fulfilled more often the serum creatinine (SCr) > 3.0x criterion in AKI-Stage3, AoCKD subjects reached SCr > 4.0 mg/dL criterion more frequently. AKI severity was associated with in-hospital mortality independently of baseline renal function. AoCKD subjects presented higher mortality when fulfilling AKI-Stage1 criteria or SCr > 3.0x criterion within AKI-Stage3. The relationship between mortality and associated risk factors, such as the net increase of SCr or AoCKD status, fluctuated depending on AKI stage and stage criteria sub-strata. AoCKD patients that fulfil SCr increment rate criteria may be exposed to more severe insults, possibly explaining the higher mortality. AoCKD may constitute a unique clinical syndrome. Adequate staging criteria may help prompt diagnosis and administration of appropriate therapy.
PB MDPI
SN 2077-0383
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/50919
UL https://uvadoc.uva.es/handle/10324/50919
LA eng
NO Journal of Clinical Medicine (JCM), 2019, vol. 8, n. 9, 1323
NO Producción Científica
DS UVaDOC
RD 27-jul-2024