RT info:eu-repo/semantics/article
T1 Risk factors for graft loss and mortality after renal transplantation according to recipient age: a prospective multicentre study
A1 Morales Cerdán, Jose Maria
A1 Marcén Letosa, Roberto
A1 Castillo Caba, Domingo del
A1 Andrés Belmonte, Amado
A1 Gonzalez Molina, Miguel
A1 Oppenheimer Salinas, Federico
A1 Serón Micas, Daniel
A1 Gil Vernet, Salvador
A1 Lampreave Gaztelu, Ildefonso
A1 Gainza Ríos, Francisco Javier
A1 Valdés Cañedo, Francisco Antonio
A1 Cabello Díaz, Mercedes
A1 Anaya Fernández-Lomana, Fernando
A1 Escuín Sancho, Fernando
A1 Arias Rodríguez, Manuel
A1 Pallardó Mateu, Luis
A1 Bustamante Bustamante, Jesús
K1 Riñones - Trasplante
K1 Mortalidad
K1 Survival
K1 Supervivencia
K1 Riñones - Enfermedades
K1 3205.06 Nefrología
K1 3205.01 Cardiología
AB Background. To describe the causes of graft loss, patient death and survival figures in kidney transplant patients in Spain based on the recipient’s age. Methods. The results at 5 years of post-transplant cardiovascular disease (CVD) patients, taken from a database on CVD, were prospectively analysed, i.e. a total of 2600 transplanted patients during 2000–2002 in 14 Spanish renal transplant units, most of them receiving their organ from cadaver donors. Patients were grouped according to the recipient’s age: Group A: <40 years, Group B: 40–60 years and Group C: >60 years. The most frequent immunosuppressive regimen included tacrolimus, mycophenolate mofetil and steroids. Results. Patients were distributed as follows: 25.85% in Group A (>40 years), 50.9% in Group B (40–60 years) and 23.19% in Group C (>60). The 5-year survival for the different age groups was 97.4, 90.8 and 77.7%, respectively. Death-censored graft survival was 88, 84.2 and 79.1%, respectively, and non death-censored graft survival was 82.1, 80.3 and 64.7%, respectively. Across all age groups, CVD and infections were the most frequent cause of death. The main causes of graft loss were chronic allograftdysfunction in patients <40 years old and death with functioning graft in the two remaining groups. In the multivariate analysis for graft survival, only elevated creatinine levels and proteinuria >1 g at 6 months post-transplantation were statistically significant in the three age groups. The patient survival multivariate analysis did not achieve a statistically significant common factor in the three age groups.Conclusions. Five-year results show an excellent recipient survival and graft survival, especially in the youngest age group. Death with functioning graft is the leading cause of graft loss in patients >40 years. Early improvement of renal function and proteinuria together with strict control of cardiovascularrisk factors are mandatory.
PB Oxford University Press
SN 0931-0509
YR 2012
FD 2012
LK https://uvadoc.uva.es/handle/10324/50939
UL https://uvadoc.uva.es/handle/10324/50939
LA eng
NO Nephrology Dialysis Transplantation, 2012, vol. 27,  supl. 4, p. 39–46
NO Producción Científica
DS UVaDOC
RD 23-abr-2024