RT info:eu-repo/semantics/article
T1 Biosemiotics comprehension of PrP code and prion disease
A1 Romay Coca, Juán
A1 Eraña, Hasier
A1 Castilla, Joaquín
K1 Protein misfolding
K1 Plegamiento de proteínas
K1 Neurodegenerative diseases
K1 Enfermedades neurodegenerativas
K1 Biosociology
K1 Biosociología
AB Prions or PrPSc (prion protein, Scrapie isoform) are proteins with an aberrant three-dimensional conformation that present the ability to alter the three-dimensional structure of natively folded PrPC (prion protein, cellular isoform) inducing its abnormal folding, giving raise to neurological diseases known as Transmissible spongiforms encephalopathies (TSEs) or prion diseases. In this work, through a biosemiotic study, we will analyze the molecular code of meanings that are known in the molecular pathway of PrPC and how it is altered in prion diseases. This biosemiotic code presents a socio-semiotic correlate in organisms that could be unraveled with the ultimate goal of understanding the code of signs that mediates the process. Finally, we will study recent works that indicate possible relationships in the code between prion proteins and other proteins such as the tau protein and alpha-synuclein to evaluate if it is possible that there is a semiotic expansion of the PrP code and prion diseases in the meaning recently expounded by Prusiner, winner of the Nobel Prize for describing these unusual pathological processes.
PB Elsevier
SN 0303-2647
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/50942
UL https://uvadoc.uva.es/handle/10324/50942
LA eng
NO Biosystems, 2021, vol. 210, 104542
NO Producción Científica
DS UVaDOC
RD 17-jul-2024