RT info:eu-repo/semantics/article
T1 Renal transplantation in the modern immunosuppressive era in Spain: four-year results from a multicenter database focus on post-transplant cardiovascular disease
A1 Morales Cerdán, Jose Maria
A1 Marcén Letosa, Roberto
A1 Andrés Belmonte, Amado
A1 Gonzalez-Molina Alcaide, Miguel
A1 Castillo Caba, Domingo del
A1 Cabello Díaz, Mercedes
A1 Capdevila Plaza, Luis
A1 Campistol Plana, Josep María
A1 Oppenheimer Salinas, Federico
A1 Serón Micas, Daniel
A1 Gil Vernet, Salvador
A1 Lampreave Gaztelu, Ildefonso
A1 Valdés Cañedo, Francisco Antonio
A1 Anaya Fernández-Lomana, Fernando
A1 Escuín Sancho, Fernando
A1 Arias Rodríguez, Manuel
A1 Pallardó Mateu, Luis
A1 Bustamante Bustamante, Jesús
K1 Riñones - Trasplante
K1 Mortalidad
K1 Cardiovascular, Aparato - Enfermedades
K1 Isquemia
K1 3205.06 Nefrología
K1 3205.01 Cardiología
AB To evaluate cardiovascular disease (CVD) after renal transplantation we established a CVD database(no-intervention) including all patients transplanted among 2000–2002 in 14 hospitals from Spain (Renal Forum Group) (n¼2600). They were prospective followed annually thereafter and we present herein the most important results concerning survival figures and CVD at four years. Mean recipient age was 49.7±13.7 years: 16% retransplanted and 12.5% hyperimmunized. Tacrolimus, mycophenolatemofetil, and steroids was used in 63%. Acute rejection (AR) rate at 1 year was 14.8%. Graft and patient survival at 48 months were 85.6% (death censored) and 91.7% respectively. The first cause of graft loss was vascular in the first year, death with function during the 2–3 years, and chronic allograft nephropathy at the 4th year. Donor age, time on dialysis, acute tubular necrosis (ATN), AR, SCr at 6months, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in the first year, and systolic blood pressure at 24 months were independent risk factors for graft loss at 4th year. The first cause of death was CVD (predominantly ischemic heart disease (IHD) in the first year). Recipient age, ATN, and SCr at 6 months were independent predictors of mortality. Despiteworsening of donor age, comorbidity, and advanced age of recipients, survival figures at four years are considered good in our Spanish non-selected population. Cardiovascular mortality is the most important cause of death and graft loss particularly, IHD in the first year. Therefore, to decrease post-transplant mortality a careful cardiovascular evaluation and treatment in the waiting list and a close follow-up of patients after transplantation is mandatory.
PB International Society of Nephrology
SN 0085-2538
YR 2008
FD 2008
LK https://uvadoc.uva.es/handle/10324/50957
UL https://uvadoc.uva.es/handle/10324/50957
LA eng
NO Kidney International, 2008, vol. 74, supl. 111, p. S94-S99
NO Producción Científica
DS UVaDOC
RD 25-abr-2024