RT info:eu-repo/semantics/article
T1 The impact of donor age on the results of renal transplantation
A1 Oppenheimer Salinas, Federico
A1 Aljama García, Pedro
A1 Asensio Peinado, Concepción
A1 Bustamante Bustamante, Jesús
A1 Crespo Albiach, Jose Francisco
A1 Guirado Perich, Luis
K1 Riñones - Trasplante
K1 Survival
K1 Supervivencia
K1 Riñones - Enfermedades
K1 Cardiovascular risk
K1 Riesgo cardiovascular
K1 3205.06 Nefrología
K1 3205.01 Cardiología
AB Background. The use of elderly donors is becoming more frequent. An increase in the donor’s age isassociated with a greater incidence of delayed graft function (DGF), chronic allograft nephropathy (CAN)and worse graft survival. Poor renal graft function is a risk factor for cardiovascular (CV) complicationsand, finally, for mortality of the patients. Methods. A total of 3365 adult patients transplanted in 1990 (n¼824), 1994 (n¼1075) and 1998 (n¼1466) with a functioning graft after the first year were included. The impact of donor age on renal function, DGF, acute rejection and other clinical factors was evaluated according to two donor and recipient age categories: young (<60 years old) and elderly (>60years old). Additionally, donor age was categorized by decades for the analysis of patient and graft survival, acute rejection and CV mortality. Results. Donor mean age significantly increased during the three transplantation periods. A total of 478 out of 3365 donors were older than 60 years. Elderly donors showed an increased risk of DGF (38.9 vs 28.8%) and CAN (56.8 vs 46.2%). Mean serum creatinine at 3 and 12 months and proteinuria were significantly higher in the old donor group. Incidence and severity of acute rejection were similar in both groups. Graft and patient survival were significantly lower in the old donor group. Also, risk of mortality due to CV events was also significantly higher. A linear increase in risk of graft loss, patient death or CV mortality was observed when donor age was divided into 10 year increase subsets. Conclusions. Donor age is a strong predictor of CAN and graft loss. Patient survival is also affected by donor age, particularly by a higher risk of CV mortality.
PB Oxford University Press
SN 0931-0509
YR 2004
FD 2004
LK https://uvadoc.uva.es/handle/10324/50969
UL https://uvadoc.uva.es/handle/10324/50969
LA eng
NO Nephrology Dialysis Transplantation, 2004, vol. 19,  supl. 3, p. 11–15
NO Producción Científica
DS UVaDOC
RD 12-jul-2024