RT info:eu-repo/semantics/article
T1 Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis
A1 Valentín Bravo, Francisco Javier
A1 García Onrubia, Luis
A1 Andrés Iglesias, Cristina
A1 Valentín Bravo, Eduardo
A1 Martín Vallejo, Javier
A1 Pastor Jimeno, José Carlos
A1 Usategui Martín, Ricardo
A1 Pastor Idoate, Salvador
K1 Complications
K1 Intraocular tamponade
K1 Pars plana vitrectomy
K1 Silicone
K1 Vitreous substitute
K1 Oil
K1 32 Ciencias Médicas
AB Silicone oil (SO) still represents the main choice for long-term intraocular tamponade in complicated vitreoretinal surgery. This review compared the complications associated with the use of SO and other vitreous substitutes after pars plana vitrectomy in patients with different underlying diseases. Meta-analysis was conducted in accordance with PRISMA guidelines. We retrieved randomized clinical trials (RCTs), retrospective case–control and cohort studies evaluating the risk of using SO, published between 1994 and 2020, conducting a computer-based search of the following databases: PubMed, Web of Science, Scopus and Embase. Primary outcome was the rate of complications such as intraocular hypertension, retinal re-detachment, unexpected vision loss or hypotony. Secondary outcome was to compare the rate of adverse events of different SO viscosities, especially emulsification. Forty-three articles were included. There were significant differences in intraocular hypertension (p = 0.0002, OR = 1.66; 95% CI = 1.27–2.18) and the rate of retinal re-detachment (p < 0.0009, OR = 0.65; 95% CI = 0.50–0.64) between SO and other agents, including placebo. However, there were no differences in other complication rates. Silicone oil (SO)-emulsification rate was non-significantly higher in low than high SO viscosity, and results from other complications were comparable in both groups. The high quality of most of the studies included in this study is noteworthy, which provides some certainty to the conclusions. Among them is the high variability of the SO residence time. The fact that ocular hypertension and not hypotension is related to SO use. A clear relationship is not found for the so-called unexplained vision loss, which affects a significant percentage of eyes. Re-detachment cases are less if SO is used and that surprisingly there does not seem to be a relationship in the percentage of emulsification between the low- and high-viscosity silicones. All these data warrant more standardized prospective studies.
PB Wiley
SN 1755-375X
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/51015
UL https://uvadoc.uva.es/handle/10324/51015
LA eng
NO Acta Ophthalmologica, 2021.
NO Producción Científica
DS UVaDOC
RD 17-jul-2024