RT info:eu-repo/semantics/article
T1 Role of the rs10401670 variant in the resistin gene on the metabolic response after weight loss secondary to a high‐fat hypocaloric diet with a Mediterranean pattern
A1 Luis Román, Daniel Antonio de
A1 Aller de la Fuente, Rocío
A1 Izaola Jauregui, Olatz
A1 Primo Martín, David
K1 High‐fat hypocaloric diet
K1 Insulin resistance
K1 Resistin
K1 rs10401670 gene variant
K1 32 Ciencias Médicas
AB Background:The single nucleotide polymorphism (SNP) (rs10401670) of theRETNgene has been associated with metabolic disorder in obese subjects andhas scarcely been evaluated after dietary interventions. The present studyaimed to analyse the effects of thers10401670 RETNgene polymorphismon metabolic changes secondary to weight loss and secondary to a high‐fathypocaloric diet with a Mediterranean dietary pattern.Methods:A Caucasian population comprising 284 obese patients withoutdiabetes mellitus was analysed. Before and after 3 months of a high‐fathypocaloric diet with a Mediterranean pattern, an anthropometric evaluation,an assessment of nutritional intake and a biochemical analysis were per-formed. A statistical analysis was conducted for the combinedCTandTTas agroup and for wild‐typeCCas a second group.Results:Decreases in weight, body mass index (BMI), fat mass, systolic bloodpressure and waist circumference were similar in both genotypes groups. InTallele carriers, insulin, homeostatic model assessment for insulin resistance(HOMA‐IR), triglycerides and C‐reactive protein levels were decreased.The decrease in these parameters was statistically significant for triglycerides(−22.3 ± 9.3 mg  dl–1:p= 0.03),  C‐reactive  protein  (−2.8 ± 0.5 mg  dl–1:p= 0.03), insulin (−7.4 ± 2.9 mUI L–1:p= 0.03) and HOMA‐IR (−2.4 ± 1.0:p= 0.02). Leptin levels were decreased in both genotypes groups after thehypocaloric diet, as well as the anthropometric parameters BMI, weight, waistcircumference and fat mass. Resistin and adiponectin levels remained un-changed in both groups.Conclusions:In the present study, we have detected a significant associationbetween theTallele of this SNP and a better response of insulin resistance,triglycerides and C‐reactive protein compared to nonTallele carriers afterweight loss with a high‐fat hypocaloric diet and a Mediterranean diet.
PB Wiley
SN 0952-3871
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/51185
UL https://uvadoc.uva.es/handle/10324/51185
LA eng
NO Journal of Human Nutrition and Dietetics, 2021, p. 1-9
NO Producción Científica
DS UVaDOC
RD 22-dic-2024