RT info:eu-repo/semantics/article
T1 Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
A1 Escobedo Monge, Marlene Fabiola
A1 Torres Hinojal, María Carmen
A1 Barrado Esteban, Enrique
A1 Escobedo Monge, María Antonieta
A1 Marugán de Miguelsanz, José Manuel
A1 Parodi Román, Joaquín
K1 Hypocupremia
K1 Hipocupremia
K1 Hypercupremia
K1 Hipercupremia
AB Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropomet-ric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaning-fully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.
PB MDPI
SN 2072-6643
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/51383
UL https://uvadoc.uva.es/handle/10324/51383
LA eng
NO Nutrients, 2021, vol. 13, 3578
DS UVaDOC
RD 18-nov-2024