RT info:eu-repo/semantics/article
T1 Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
A1 Nakanishi, Tomoko
A1 Pigazzini, Sara
A1 Degenhardt, Frauke
A1 Cordioli, Mattia
A1 Butler Laporte, Guillaume
A1 Maya Miles, Douglas
A1 Nafría Jiménez, Beatriz
A1 Bouysran, Youssef
A1 Niemi, Mari
A1 Palom, Adriana
A1 Ellinghaus, David
A1 Khan, Atlas
A1 Martínez Bueno, Manuel
A1 Rolker, Selina
A1 Amitano, Sara
A1 Roade Tato, Luisa
A1 Fava, Francesca
A1 Spinner, Christoph D.
A1 Prati, Daniele
A1 Bernardo Ordiz, David
A1 García, Federico
A1 Darcis, Gilles
A1 Fernández Cadenas, Israel
A1 Holter, Jan Cato
A1 Banales, Jesús
A1 Frithiof, Robert
A1 Kiryluk, Krzysztof
A1 Duga, Stefano
A1 Asselta, Rosanna
A1 Pereira, Alexandre
A1 Romero Gómez, Manuel
A1 Bujanda, Luis
A1 Hov, Johannes R.
A1 Migeotte, Isabelle
A1 Renieri, Alessandra
A1 Planas, Anna
A1 Ludwig, Kerstin
A1 Buti, Maria
A1 Rahmouni, Souad
A1 Alarcón Riquelme, Marta Eugenia
A1 Schulte, Eva Christina
A1 Franke, Andre
A1 Karlsen, Tom
A1 Valenti, Luca
A1 Zeberg, Hugo
A1 Richards, Brent
A1 Ganna, Andrea
K1 COVID-19 (Enfermedad)
AB Background: There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition. Methods: We combined individual level data from 13,888 COVID-19 patients (n = 7185 hospitalized) from 17 cohorts in 9 countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related complications, and laboratory values. We next performed metaanalyses using FinnGen and the Columbia University COVID-19 Biobank. Results: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (HR, 1.4; 95% CI, 1.2–1.7). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (OR, 2.1; 95% CI, 1.6–2.6), venous thromboembolism (OR, 1.7; 95% CI, 1.2–2.4), and hepatic injury (OR, 1.5; 95% CI, 1.2–2.0). Risk allele carriers age 60 years and younger had higher odds of death or severe respiratory failure (OR, 2.7; 95% CI, 1.8–3.9) compared with those of more than 60 years (OR, 1.5; 95% CI, 1.2–1.8; interaction, P = 0.038). Among individuals 60 years and younger who died or experienced severe respiratory failure, 32.3% were risk-variant carriers compared with 13.9% of those not experiencing these outcomes. This risk variant improved the prediction of death or severe respiratory failure similarly to, or better than, most established clinical risk factors. Conclusions: The major common COVID-19 genetic risk factor is associated with increased risks of morbidity and mortality, which are more pronounced among individuals 60 years or younger. The effect was similar in magnitude and more common than most established clinical risk factors, suggesting potential implications for future clinical risk management.
PB American Society for Clinical Investigation
SN 1558-8238
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/51610
UL https://uvadoc.uva.es/handle/10324/51610
LA eng
NO The Journal of Chemical investigation, 2021, vol. 131, n. 23, 152386
NO Producción Científica
DS UVaDOC
RD 30-abr-2024