RT info:eu-repo/semantics/article
T1 Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers
A1 Acosta Rodríguez, Sergio
A1 Quintanilla Sierra, Luis
A1 Mbundi, Lubinda
A1 Reboto Rodríguez, Virginia
A1 Rodríguez Cabello, José Carlos
K1 Elastin-like recombinamers
K1 Recombinantes tipo elastina
K1 Extracellular matrix proteins
K1 Proteínas de matriz extracelular
AB In the development of tissue engineering strategies to replace, remodel, regenerate, or support damaged tissue, the development of bioinspired biomaterials that recapitulate the physicochemical characteristics of the extracellular matrix has received increased attention. Given the compositional heterogeneity and tissue-to-tissue variation of the extracellular matrix, the design, choice of polymer, crosslinking, and nature of the resulting biomaterials are normally depended on intended application. Generally, these biomaterials are usually made of degradable or nondegradable biomaterials that can be used as cell or drug carriers. In recent years, efforts to endow reciprocal biomaterial–cell interaction properties in scaffolds have inspired controlled synthesis, derivatization, and functionalization of the polymers used. In this regard, elastin-like recombinant proteins have generated interest and continue to be developed further owing to their modular design at a molecular level. In this review, the authors provide a summary of key extracellular matrix features relevant to biomaterials design and discuss current approaches in the development of extracellular matrix-inspired elastin-like recombinant protein based biomaterials.
PB Wiley
SN 1616-3028
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/51661
UL https://uvadoc.uva.es/handle/10324/51661
LA eng
NO Advanced functional materials, 2020, vol. 30, n. 44, 1909050
NO Producción Científica
DS UVaDOC
RD 07-may-2024