RT info:eu-repo/semantics/article
T1 Event-related potentials associated to N-back test performance in schizophrenia
A1 Arjona Valladares, Antonio
A1 Fondevila Estévez, Sabela
A1 Fernández Linsenbarth, Inés
A1 Díez Revuelta, Álvaro
A1 Ruiz Sanz, Francisco Javier
A1 Rodríguez Lorenzana, Alberto
A1 Molina Rodríguez, Vicente
K1 Schizophrenia
K1 Esquizofrenia
K1 N-back test
K1 Test n-back
AB Mapping of Event-Related Potentials (ERP) associated with auditory and visual odd-ball paradigms has shown consistent differences between healthy controls and schizophrenia patients. It may be hypothesized that higher task attentional/cognitive demand will result in larger differences in these paradigms, which may help understanding the substrates of cognitive deficits in this syndrome. To this aim, we performed an EEG study comparing the effects of increasing the attentional/cognitive load of an auditory N-back task on the Event-Related Potential in 50 subjects with schizophrenia (11 first episodes) and 35 healthy controls. We considered a post-target window of 1000 ms to explore possible between groups differences in N100, P300, and Late Slow Wave (LSW), and compared these components between 0-back (‘lower attentional/cognitive load) and 1-back (‘higher attentional/cognitive load’) conditions. Our results showed that N100 and LSW amplitude increase from 0- to 1-back condition was significantly larger in healthy controls compared to schizophrenia patients. Furthermore, LSW amplitude difference between 0- and 1-back conditions positively correlated with performance in the behavioral cognitive assessment. Taken together, these results support that higher task attentional/cognitive load (0-back vs. 1-back condition) increase N100 amplitude differences and reveal new findings related to the LSW component in schizophrenia.
PB Elsevier
SN 0278-5846
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/51709
UL https://uvadoc.uva.es/handle/10324/51709
LA eng
NO Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, vol. 111, 110347
NO Producción Científica
DS UVaDOC
RD 04-dic-2024