RT info:eu-repo/semantics/article
T1 The role of Ca2+ signaling in aging and neurodegeneration: Insights from caenorhabditis elegans models
A1 Álvarez Martín, Javier
A1 Álvarez Illera, María Pilar
A1 García Casas, Paloma
A1 Fonteriz García, Rosalba Inés
A1 Montero Zoccola, María Teresa
K1 Calcium
K1 Calcio
K1 Caenorhabditis elegans
K1 Neurodegeneration
K1 Neurodegeneración
AB Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling is one of the key events in the development of neurodegenerative processes, an idea called the “calcium hypothesis” of neurodegeneration. Caenorhabditis elegans (C. elegans) is a very good model for the study of aging and neurodegeneration. In fact, many of the signaling pathways involved in longevity were first discovered in this nematode, and many models of neurodegenerative diseases have also been developed therein, either through mutations in the worm genome or by expressing human proteins involved in neurodegeneration (β-amyloid, α-synuclein, polyglutamine, or others) in defined worm tissues. The worm is completely transparent throughout its whole life, which makes it possible to carry out Ca2+ dynamics studies in vivo at any time, by expressing Ca2+ fluorescent probes in defined worm tissues, and even in specific organelles such as mitochondria. This review will summarize the evidence obtained using this model organism to understand the role of Ca2+ signaling in aging and neurodegeneration.
PB MDPI
SN 2073-4409
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/52623
UL https://uvadoc.uva.es/handle/10324/52623
LA eng
NO Cells, 2020, vol. 9, n. 1, 204
NO Producción Científica
DS UVaDOC
RD 22-nov-2024