RT info:eu-repo/semantics/article
T1 Long-term effect of combination of creatine monohydrate plus β-Hydroxy β-Methylbutyrate (HMB) on exercise-induced muscle damage and anabolic/catabolic hormones in elite male endurance athletes
A1 Fernández Landa, Julen
A1 Fernández Lázaro, Diego
A1 Calleja González, Julio
A1 Caballero García, Alberto
A1 Córdova Martínez, Alfredo
A1 León Guereño, Patxi
A1 Mielgo Ayuso, Juan Francisco
K1 Muscle damage
K1 Daño muscular
K1 Lactate dehydrogenase
K1 Lactato deshidrogenasa
K1 Creatine kinase
K1 Creatina quinasa
K1 Testosterone
K1 Testosterona
AB Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of 10 weeks of CrM plus HMB supplementation on EIMD and anabolic/catabolic hormones. This study was a double-blind, placebo-controlled trial where participants (n = 28) were randomized into four different groups: placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7). Before (baseline, T1) and after 10 weeks of supplementation (T2), blood samples were collected from all rowers. There were no significant differences in the EIMD markers (aspartate aminotransferase, lactate dehydrogenase, and creatine kinase) among groups. However, we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = −63.85% vs. CrMG + HMBG = −37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation.
PB MDPI
SN 2218-273X
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/52632
UL https://uvadoc.uva.es/handle/10324/52632
LA eng
NO Biomolecules, 2020, vol. 10, n. 1, 140
NO Producción Científica
DS UVaDOC
RD 23-abr-2024