RT info:eu-repo/semantics/article
T1 Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
A1 Mateos Olivares, Milagros
A1 Sobas Abad, Eva María
A1 Puertas Neyra, Kevin Louis
A1 Peralta Ramírez, María Isabel
A1 González Pérez, Raquel
A1 Martín Vallejo, Javier
A1 García Vázquez, Carmen
A1 Coco Martín, Rosa María
A1 Pastor Jimeno, José Carlos
A1 Pastor Idoate, Salvador
A1 Usategui Martín, Ricardo
K1 Retinitis pigmentosa
K1 Hair cortisol
K1 Pelo - Cortisol
K1 Molecular biomarkers
K1 Biomarcadores moleculares
AB Purpose: Retinitis pigmentosa (RP) patients commonly experience negative psychological states due to their progressive and unpredictable loss of vision and visual variations related to stress. The aim of this study was to examine hair cortisol concentrations (HCCs), which is usually associated with chronic stress, pretending to unveil possible associations between underlying psychological factors and disease severity in RP patients.Methods: Seventy-eight RP patients and 148 healthy controls were included in this study. A complete ophthalmological exam was performed in all patients to grade into severity disease groups. Perceived stress and trait-anxiety were measured by the State-Trait Anxiety Inventory (STAI) questionnaire.Results: Fifty-two (67%) patients had severe RP and 26 (33%) mild-moderate RP. Fifty-eight (58,9%) patients reported severely levels of stress and 18 (23.,1%) highly levels assessed by STAI questionnaire. RP patients exhibited higher HCCs (500.04 ± 120.99 pg/mg) than in controls (136.17 ± 60.51 pg/mg; p < 0.001). Severe RP patients had significant higher HCCs than mild-moderate patients differing in 274.27 pg/mg (p < 0.001). RP severity grade and perceived anxiety levels in the questionaries were not associated. Group differences were not affected by relevant covariates (age, grade of severity, stress status, and gender).Conclusions: HCC seems an effective biomarker associated with chronic stress in RP patients. This study shows that HCC in patients with RP are elevated compared to population-based controls, and association between HCC and RP severity was found. Future research is needed to characterize the effect of untreated negative psychological states on progression of the disease if any.
PB Elsevier
SN 0014-4835
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/53072
UL https://uvadoc.uva.es/handle/10324/53072
LA eng
NO Experimental Eye Research, 2022, vol. 219, 109019
NO Producción Científica
DS UVaDOC
RD 12-sep-2024