RT info:eu-repo/semantics/article T1 The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis A1 Jiménez del Barrio, Sandra A1 Cadellans Arróniz, Aida A1 Ceballos Laita, Luis A1 Estébanez de Miguel, Elena A1 López de Celis, Carles A1 Bueno Gracia, Elena A1 Pérez Bellmunt, Albert K1 Carpal tunnel syndrome K1 Manual therapy K1 Median nerve K1 Neuropathies K1 Meta-analysis K1 32 Ciencias Médicas AB Aim of the study Systematic review and meta-analysis to assess the effectiveness of manual therapy in improving carpaltunnel syndrome (CTS) symptoms, physical function, and nerve conduction studies.Method MEDLINE, Web of Science, SCOPUS, Cochrane Library, TRIP database, and PEDro databases were searchedfrom the inception to September 2021. PICO search strategy was used to identify randomized controlled trials applyingmanual therapy on patients with CTS. Eligible studies and data extraction were conducted independently by two reviewers.Methodology quality and risk of bias were assessed by PEDro scale. Outcomes assessed were pain intensity, physical func-tion, and nerve conduction studies.Results Eighty-one potential studies were identified and six studies involving 401 patients were finally included. Pain inten-sity immediately after treatment showed a pooled standard mean difference (SMD) of − 2.13 with 95% confidence interval(CI) (− 2.39, − 1.86). Physical function with Boston Carpal Tunnel Syndrome Questionnaire (BCTS-Q) showed a pooledSMD of − 1.67 with 95% CI (− 1.92, − 1.43) on symptoms severity, and a SMD of − 0.89 with 95% CI (− 1.08, − 0.70) onfunctional status. Nerve conduction studies showed a SMD of− 0.19 with 95% CI (−0.40, − 0.02) on motor conduction anda SMD of − 1.15 with 95% CI (− 1.36, − 0.93) on sensory conduction.Conclusions This study highlights the effectiveness of manual therapy techniques based on soft tissue and neurodynamicmobilizations, in isolation, on pain, physical function, and nerve conduction studies in patients with CTS. PB Springer SN 0341-2695 YR 2021 FD 2021 LK https://uvadoc.uva.es/handle/10324/53350 UL https://uvadoc.uva.es/handle/10324/53350 LA eng NO International Orthopaedics, 2021, vol. 46, n. 2, p. 301-312. NO Producción Científica DS UVaDOC RD 17-jul-2024