RT info:eu-repo/semantics/article
T1 Topographically guided hierarchical mineralization
A1 Deng, X.
A1 Hasan, A.
A1 Elsharkawy, S.
A1 Tejeda Montes, E.
A1 Tarakina, N.V.
A1 Greco, G.
A1 Nikulina, E
A1 Stormonth-Darling, J.M.
A1 Convery, N.
A1 Rodríguez Cabello, José Carlos
A1 Boyde, A.
A1 Gadegaard, N.
A1 Pugno, N.M.
A1 Al-Jawad, M.
A1 Mata, A.
K1 Fluorapatite
K1 Hierarchical mineralization
K1 Elastin
K1 Crystallization
K1 Surface topographies
K1 22 Física
AB Material platforms based on interaction between organic and inorganic phases offer enormous potential todevelop materials that can recreate the structural and functional properties of biological systems. However, thecapability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains amajor limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topog-raphies to grow spatially guided mineralized structures. We reveal how well-defined geometrical spaces definedwithin the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the microscale and macroscale.Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility ofselectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct theanisotropic growth of such structures would have important implications in the design of biomineralizing syn-thetic materials to repair or regenerate hard tissues.
PB Elsevier
SN 2590-0064
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/53934
UL https://uvadoc.uva.es/handle/10324/53934
LA eng
NO Materials Today Bio, 2021, vol. 11, p. 100119
NO Producción Científica
DS UVaDOC
RD 17-jul-2024