RT info:eu-repo/semantics/article
T1 Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study
A1 Vázquez Hernández, Amanda
A1 Martínez Plaza, Elena
A1 Fernández Martínez, Itziar
A1 Sobas Abad, Eva María
A1 González García, María Jesús
A1 Enriquez De Salamanca Aladro, Amalia
A1 Ortega, Enrique
A1 López Miguel, Alberto
A1 Calonge, Margarita
K1 Cornea
K1 Córnea
K1 Dry eye disease
K1 Ojo seco
K1 Corneal innervation
K1 Inervación corneal
K1 Refractive surgery
K1 Cirugía refractiva
AB Purpose: To describe the clinical characteristics of patients suffering from chronic dry eye (DE) and pain after refractive surgery (RS).Methods: Cross-sectional, observational, single-visit study. DE-, pain- and psychological-related symptoms were evaluated with specific questionnaires. DE-related tests evaluated tear osmolarity, conjunctival hyperemia, Meibomian gland dysfunction, tear stability and production, and ocular surface staining. Corneal mechanical sensitivity (Cochet-Bonnet) was measured pre/post topical anesthesia, and symptomatic variation post-anesthesia (anesthetic challenge test) was recorded. When pain was present, it was further categorized as neuropathic or nociceptive based on published criteria.Results: We recruited 104 patients (39.5 ± 9.5 years). Most, 85.6%, had corneal RS as opposed to intraocular RS. Migraines, anxiety, depression (p < 0.0001), and central sensitization syndromes (p = 0.0214) were more frequent post-RS than pre-RS. Persistent DE-symptoms, severe in 86.5% patients, developed in a range of 0–204 months post-RS. Dryness and pain were the two most frequent symptoms. The only DE-related tests showing abnormal values were tear osmolarity (315.2 ± 17.1 mOsm/L; normal ≤308) and tear break-up time (4.1 ± 2.5 s; normal >7). Corneal sensitivity was 55.4 ± 7.0 mm, and decreased (p < 0.0001) after topical anesthesia, 6.0 ± 10.4 mm. However, it remained pathologically elevated, ≥10 mm in 61 (58.7%) patients. The normal symptomatic post-anesthesia improvement was absent in 58 (55.7%) patients. Ocular pain was present in 82 (78.8%) patients, and it was categorized as neuropathic in 66 (80.5%) of them, 63.5% of the entire cohort.Conclusions: Chronic ocular pain and its neuropathic subtype were diagnosed in 78.8% and 63.5% respectively of patients seeking consultation for persistent symptomatic DE post-RS.
PB Elsevier
SN 1542-0124
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/54549
UL https://uvadoc.uva.es/handle/10324/54549
LA eng
NO The Ocular Surface, 2022,  vol. 26, p.  63-74
NO Producción Científica
DS UVaDOC
RD 17-jul-2024