RT info:eu-repo/semantics/article
T1 Polymorphisms in receptors involved in opsonic and nonopsonic phagocytosis, and correlation with risk of infection in oncohematology patients
A1 Herrero Sánchez, María del Carmen
A1 Angomas Jimenez, Eduardo B.
A1 Ramón Sánchez, Cristina de
A1 Tellería Orriols, Juan José
A1 Corchete Sánchez, Luis Antonio
A1 Alonso Martín, Sara
A1 Ramos Sánchez, María del Carmen
A1 Peñarrubia Ponce, María Jesús
A1 Márquez Piñeiro, Saioa
A1 Fernández García, María Nieves
A1 García Frade, Luis Javier
A1 Crespo Sánchez, Mariano
K1 Medical microbiology
K1 Micosis
K1 Cáncer - Pacientes
K1 Oncohematología
K1 Fungal infection
K1 3207.08 Hematología
K1 3201.01 Oncología
AB High-risk hematological malignancies are a privileged setting for infection by opportunistic microbes, with invasive mycosis being one of the most serious complications. Recently, genetic background has emerged as an unanticipated risk factor. For this reason, polymorphisms for genes encoding archetypal receptors involved in the opsonic and nonopsonic clearance of microbes, pentraxin-3 (PTX3) andDectin-1, respectively, were studied and correlated with the risk of infection. Fungal, bacterial, and viral infections were registered for a group of 198 patients with highrisk hematological malignancies. Polymorphisms for the pentraxin-3 gene (PTX3) showed a significant association with the risk of fungal infection by Candida spp. and, especially, by Aspergillus spp. This link remained even for patients undergoing antifungal prophylaxis, thus demonstrating the clinical relevance of PTX3 in the defense against fungi. CLEC7A polymorphisms did not show any definite correlation with the risk of invasivemycosis, nor did they influence the expression of Dectin-1 isoforms generated by alternative splicing. The PTX3 mRNA expression level was significantly lower in samples from healthy volunteers who showed these polymorphisms, although no differences were observed in the extents of induction elicited by bacterial lipopolysaccharide and heat-killed Candida albicans, thus suggesting that the expression ofPTX3 at the start of infection may influence the clinical outcome. PTX3 mRNA expression can be a good biomarker to establish proper antifungal prophylaxis in immunodepressed patients.
PB American Society for Microbiology
SN 0019-9567
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/55117
UL https://uvadoc.uva.es/handle/10324/55117
LA eng
NO Infection and Immunity, 2018, Vol. 86, Nº. 12, 15 pp.
NO Producción Científica
DS UVaDOC
RD 24-nov-2024