RT info:eu-repo/semantics/article
T1 Unveiling the shape of N-Acetylgalactosamine: A cancer-associated sugar derivative
A1 Aguado Vesperinas, Raúl
A1 Sanz Novo, Miguel
A1 Mata, Santiago
A1 León Ona, Iker
A1 Alonso Hernández, José Luis
K1 Chemical structure
K1 Estructura química
K1 Hydroxyls
K1 Hidroxilos
K1 Molecular structure
K1 Estructura molecular
K1 Noncovalent interactions
K1 Interacciones no covalentes
AB In the present work, we report the first rotational study of N-acetylgalactosamine, a cancer-associated sugar derivative, by means of high-resolution rotational spectroscopy. Two different conformers have been conclusively characterized using broadband Fourier transform microwave spectroscopy coupled with a laser ablation vaporization system. Additionally, we performed a comprehensive analysis of the intramolecular interactions that govern these structures, which allowed us to both characterize the existence of intramolecular hydrogen bond networks that drive the intrinsic conformation panorama of N-acetylgalactosamine and further rationalize the biological role of this aminosugar derivative as part of the Tn antigen.
PB American Chemical Society
SN 1089-5639
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/55700
UL https://uvadoc.uva.es/handle/10324/55700
LA eng
NO The Journal of Physical Chemistry A, 2022, vol. 126, n. 42, p. 7621–7626
NO Producción Científica
DS UVaDOC
RD 22-nov-2024