RT info:eu-repo/semantics/article
T1 Effects of Zinc supplementation on nutritional status in children with chronic kidney disease: A randomized trial
A1 Escobedo Monge, Marlene Fabiola
A1 Ayala Macedo, Guido
A1 Sakihara, Graciela
A1 Peralta, Silvia
A1 Almaraz Gómez, Ana
A1 Barrado Esteban, Enrique
A1 Marugán de Miguelsanz, José Manuel
K1 Zinc
K1 Hypozincemia
K1 Hipozincemia
K1 Kidney - Diseases
K1 Riñones - Enfermedades
AB Background: Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development. Objective: The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children. Methods: A randomized-trial multicentric study was conducted in 48 CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or 15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis were performed. Hypozincemia was determined by serum zinc concentration (SZC) using atomic absorption spectrophotometry. The positive or negative change in patients’ body mass index (BMI) Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the effect of ZS. Results: Mean SZC was normal before and after ZS. Despite ZS, there were no significant changes in serum albumin, zinc and CRP levels. A positive and significant association was observed between SZC and serum albumin before (p = 0.000) and after (p = 0.007) ZS. In both groups of ZS, there was a small but positive and significant change in body mass and normalization in BMI Z-score, hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS. Conclusions: Zinc supplementation may be beneficial for nutritional status in children and adolescents with CKD.
PB MDPI
SN 2072-6643
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/55758
UL https://uvadoc.uva.es/handle/10324/55758
LA eng
NO Nutrients 2019, vol. 11, n. 11, 2671
NO Producción Científica
DS UVaDOC
RD 22-nov-2024