RT info:eu-repo/semantics/article
T1 Retinoic acid, under cerebrospinal fluid control, induces neurogenesis during early brain development
A1 Alonso Revuelta, María Isabel
A1 Carnicero Gila, Estela María
A1 Carretero, Raquel
A1 Mano Bonín, Anibal de la
A1 Moro Balbás, José Antonio
A1 Lamus Molina, José Francisco
A1 Martín, Cristina
A1 Gato Casado, Ángel Luis
K1 Etinoic acid
K1 Embryonic cerebrospinal fluid
K1 Neurogenesis
K1 24 Ciencias de la Vida
K1 32 Ciencias Médicas
AB One of the more intriguing subjects in neuroscience is how a precursor or stemcell is induced to differentiate into a neuron. Neurogenesis begins early in brain developmentand suddenly becomes a very intense process, which is related with the influence ofRetinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that―in vivo‖ embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic IsthmicRetinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelialprecursors, inducing a significant increase in neurogenesis. This effect is mediated by theRetinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge ofembryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
PB MDPI
SN 2221-3759
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/57503
UL https://uvadoc.uva.es/handle/10324/57503
LA eng
NO Journal of Developmental Biology, 2014, vol. 2, n. 2, p. 72-83
NO Producción Científica
DS UVaDOC
RD 27-dic-2024