RT info:eu-repo/semantics/article
T1 All-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system development
A1 Parada, Carolina
A1 Gato Casado, Ángel Luis
A1 Bueno i Torrens, David
K1 Fluidos orgánicos
K1 Retinol
K1 Embriología humana
K1 Cerebro - Desarrollo
AB Embryonic cerebrospinal £uid (E-CSF) is involved in the regulationof survival, proliferation and neurogenesis of neuroectodermalprogenitor cells, aswell as in the control ofmesencephalic gene expressionin collaboration with the isthmic organizer. Recently, weshowed the presence of retinol-binding protein (RBP) within theE-CSF proteome.RBP is an all-trans retinol carrier, amolecule thatcan be metabolized into retinoic acid, a morphogen involved incentral nervous system (CNS) morphogenesis and patterning.Here we demonstrate the presence of all-trans retinol within theE-CSF and analyse the dynamics of RBP and all-trans retinolwithinthis £uid, as well as the expression of retinoic acid-synthesizingenzymes during early CNS development. Our results suggesta relationship between the dynamics of these molecules andthe early events of CNS patterning.
PB Lippincott Williams and Wilkins
SN 0378-5866
YR 2008
FD 2008
LK http://uvadoc.uva.es/handle/10324/5797
UL http://uvadoc.uva.es/handle/10324/5797
LA eng
NO Developmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950
NO Producción Científica
DS UVaDOC
RD 27-abr-2024