RT info:eu-repo/semantics/article
T1 Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease
A1 Pérez Castrillon, José Luis
A1 Vega, Gemma
A1 Abad Manteca, Laura
A1 Sanz Cantalapiedra, Alberto
A1 Chaves, Jose
A1 Hernández, Gonzalo
A1 Dueñas Laita, Antonio
K1 Cardiologia - Tratamiento
K1 Vitamina D
AB Vitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, includingtype 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesteroland vitamin D share the 7-dehydrocolesterol metabolic pathway. This study evaluated thepossible effect of atorvastatin on vitamin D levels in patients with acute ischemic heartdisease. Eighty-three patients (52 men and 31 women) with an acute coronary syndrome(75 with acute myocardial infarction and 8 with unstable angina) were included. Afterdiagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D wasmeasured by high-performance liquid chromatography at baseline and at 12 months.Atorvastatin treatment produced a statistically significant decrease in cholesterol andtriglyceride levels and an increase in vitamin D levels (41   19 vs 47   19 nmol/L, p  0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion,atorvastatin increases vitamin D levels. This increase could explain some of the beneficialeffects of atorvastatin at the cardiovascular level that are unrelated to cholesterollevels.
PB Elsevier Inc.
SN 0002-9149
YR 2007
FD 2007
LK http://uvadoc.uva.es/handle/10324/5833
UL http://uvadoc.uva.es/handle/10324/5833
LA eng
NO American Journal of Cardiology, 2007, vol. 99, p. 903-905
NO Producción Científica
DS UVaDOC
RD 27-nov-2024