RT info:eu-repo/semantics/article T1 Physical exercise as a multimodal tool for COVID-19: Could it be used as a preventive strategy? A1 Fernández Lázaro, Diego A1 González Bernal, Jerónimo J. A1 Sánchez Serrano, Nerea A1 Jiménez Navascues, María Lourdes A1 Ascaso del Río, Ana A1 Mielgo Ayuso, Juan Francisco K1 COVID-19 (enfermedad) K1 Ejercicio físico K1 Medical care K1 Immune system K1 Inflammation K1 Oxidative stress K1 2412 Inmunología AB The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) is a novel coronavirus not previously recognized in humans until late 2019. On 31 December 2019, a cluster of cases of pneumonia of unspecified etiology was reported to the World Health Organization in China. The availability of adequate SARS-CoV-2 drugs is also limited, and the efficacy and safety of these drugs for COVID-2019 pneumonia patients need to be assessed by further clinical trials. For these reasons, there is a need for other strategies against COVID-19 that are capable of prevention and treatment. Physical exercise has proven to be an effective therapy for most chronic diseases and microbial infections with preventive/therapeutic benefits, considering that exercise involves primary immunological mediators and/or anti-inflammatory properties. This review aimed to provide an insight into how the implementation of a physical exercise program against COVID-19 may be a useful complementary tool for prevention, which can also enhance recovery, improve quality of life, and provide immune protection against SARS-CoV-2 virus infection in the long term. In summary, physical exercise training exerts immunomodulatory effects, controls the viral gateway, modulates inflammation, stimulates nitric oxide synthesis pathways, and establishes control over oxidative stress. PB MDPI SN 1661-7827 YR 2020 FD 2020 LK https://uvadoc.uva.es/handle/10324/58467 UL https://uvadoc.uva.es/handle/10324/58467 LA eng NO International Journal of Environmental Research and Public Health. 2020, Vol.17, Nº. 22, 8496 NO Producción Científica DS UVaDOC RD 07-ago-2024