RT info:eu-repo/semantics/article
T1 Default mode network components and its relationship with anomalous self-experiences in schizophrenia: A rs-fMRI exploratory study
A1 Roig Herrero, Alejandro
A1 Planchuelo Gómez, Álvaro
A1 Hernández García, Marta
A1 Luis García, Rodrigo de
A1 Fernández Linsenbarth, Inés
A1 Beño Ruiz de la Sierra, Rosa María
A1 Molina Rodríguez, Vicente
K1 Magnetic resonance
K1 Metacognition
K1 Parahippocampal gyrus
K1 Psychosis
K1 32 Ciencias Médicas
AB Anomalous self-experiences (ASEs) in schizophrenia have been under research for the last 20 years. However, no neuroimage studies have provided insight of the possible biological underpinning of ASEs. In this novel approach, the connectivity within the default mode network, calculated through a ROI-based analysis of functional magnetic resonance imaging data, was correlated to the ASEs scores assessed by the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) in a sample of 22 schizophrenia patients. The Pearson's correlation coefficients between IPASE scores and intrahemispheric connectivity of the parahippocampal gyrus with the isthmus cingulate cortex in both hemispheres, and right parahippocampal gyrus with the right rostral anterior cingulate cortex were positive and significant suggesting a relation between hyperactive functional connectivity and anomalous self-experiences intensity. Prior literature reported these areas to have a role in self-processing and consciousness as well as being anatomically connected. Further research with larger sample size and comparison with controls are needed to confirm the relationship of this connectivity with anomalous self-experiences.
PB Elsevier
SN 0925-4927
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/58664
UL https://uvadoc.uva.es/handle/10324/58664
LA eng
NO Psychiatry Research: Neuroimaging, 2022, vol. 324, p. 111495
NO Producción Científica
DS UVaDOC
RD 24-nov-2024