RT info:eu-repo/semantics/article
T1 Aptamer-functionalized natural protein-based polymers as innovative biomaterials
A1 Girotti, Alessandra
A1 Escalera Anzola, Sara
A1 Alonso Sampedro, Irene
A1 González Valdivieso, Juan
A1 Arias Vallejo, Francisco Javier
K1 Biomaterials
K1 Biomedicina
K1 Biopolymers
K1 Polymers in medicine
K1 Aptamers
K1 2403 Bioquímica
K1 2302.21 Biología Molecular
AB Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.
PB MDPI
SN 1999-4923
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58816
UL https://uvadoc.uva.es/handle/10324/58816
LA eng
NO Pharmaceutics,  2020, Vol.12, Nº. 11, 1115
NO Producción Científica
DS UVaDOC
RD 07-ago-2024