RT info:eu-repo/semantics/article
T1 Sarcopenia: molecular pathways and potential targets for intervention
A1 Pascual Fernández, Jorge
A1 Fernández Montero, Alejandro
A1 Córdova Martínez, Alfredo
A1 Pastor Campos, Diego
A1 Martínez Rodríguez, Alejandro
A1 Roche Collado, Enrique
K1 Muscle strength
K1 Muscle tone
K1 Aging
K1 Aging - Physiological aspects
K1 Oxidative stress
K1 Inflammation
K1 Exercise
K1 Ejercicio físico
K1 2411 Fisiología Humana
K1 2402.15 Envejecimiento Somático
AB Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass and motor function. This process accelerates the progressive muscle deterioration observed in older adults, favoring the presence of debilitating pathologies. In addition, sarcopenia leads to a decrease in quality of life, significantly affecting self-sufficiency. Altogether, these results in an increase in economic resources from the National Health Systems devoted to mitigating this problem in the elderly, particularly in developed countries. Different etiological determinants are involved in the progression of the disease, including: neurological factors, endocrine alterations, as well as nutritional and lifestyle changes related to the adoption of more sedentary habits. Molecular and cellular mechanisms have not been clearly characterized, resulting in the absence of an effective treatment for sarcopenia. Nevertheless, physical activity seems to be the sole strategy to delay sarcopenia and its symptoms. The present review intends to bring together the data explaining how physical activity modulates at a molecular and cellular level all factors that predispose or favor the progression of this deteriorating pathology.
PB MDPI
SN 1661-6596
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58822
UL https://uvadoc.uva.es/handle/10324/58822
LA eng
NO International Journal of Molecular Sciences, 2020, Vol. 21, Nº.22, 8844
NO Producción Científica
DS UVaDOC
RD 25-nov-2024