RT info:eu-repo/semantics/article
T1 Retrospective assessment of the antigenic similarity of egg-propagated and cell culture-propagated reference influenza viruses as compared with circulating viruses across influenza seasons 2002–2003 to 2017–2018
A1 Rajaram, Sankarasubramanian
A1 Suphaphiphat, Pirada
A1 van Boxmeer, Josephine
A1 Haag, Mendel
A1 Leav, Brett
A1 Iheanacho, Ike
A1 Kistler, Kristin
A1 Ortiz de Lejarazu Leonardo, Raúl
K1 Influenza
K1 Vaccine
K1 Huevos
K1 Células
K1 Cell Biology
K1 Antigens
K1 Virus
K1 Adaptation
K1 Mutation
K1 2420 Virología
AB Suboptimal vaccine effectiveness against seasonal influenza is a significant public health concern, partly explained by antigenic differences between vaccine viruses and viruses circulating in the environment. Haemagglutinin mutations within vaccine viruses acquired during serial passage in eggs have been identified as a source of antigenic variation between vaccine and circulating viruses. This study retrospectively compared the antigenic similarity of circulating influenza isolates with egg- and cell-propagated reference viruses to assess any observable trends over a 16-year period. Using annual and interim reports published by the Worldwide Influenza Centre, London, for the 2002–2003 to 2017–2018 influenza seasons, we assessed the proportions of circulating viruses which showed antigenic similarity to reference viruses by season. Egg-propagated reference viruses were well matched against circulating viruses for A/H1N1 and B/Yamagata. However, A/H3N2 and B/Victoria cell-propagated reference viruses appeared to be more antigenically similar to circulating A/H3N2 and B/Victoria viruses than egg-propagated reference viruses. These data support the possibility that A/H3N2 and B/Victoria viruses are relatively more prone to egg-adaptive mutation. Cell-propagated A/H3N2 and B/Victoria reference viruses were more antigenically similar to circulating A/H3N2 and B/Victoria viruses over a 16-year period than were egg-propagated reference viruses.
PB MDPI
SN 1661-7827
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58922
UL https://uvadoc.uva.es/handle/10324/58922
LA eng
NO International Journal of Environmental Research and Public Health. 2020, Vol.17, Nº. 15,  5423
NO Producción Científica
DS UVaDOC
RD 22-nov-2024