RT info:eu-repo/semantics/article
T1 Relationship between insulin resistance (HOMA-IR), trabecular bone score (TBS), and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal women
A1 Campillo Sánchez, Francisco
A1 Usategui Martín, Ricardo
A1 Ruiz de Temiño de la Peña, Ángela
A1 Gil, Judith
A1 Ruiz Mambrilla, Marta María
A1 Fernández Gómez, José María Fidel
A1 Dueñas Laita, Antonio
A1 Pérez Castrillon, José Luis
K1 Gynecology
K1 Endocrinology
K1 Osteoporosis
K1 HOMA-IR
K1 HbA1c
K1 vBMD
K1 TBS
K1 3D-DXA
K1 32 Ciencias Médicas
AB Background: Insulin may play a key role in bone metabolism, where the anabolic effect predominates. This study aims to analyze the relationship between insulin resistance and bone quality using the trabecular bone score (TBS) and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal women by determining cortical and trabecular compartments. Methods: A cross-sectional study was conducted in non-diabetic postmenopausal women with suspected or diagnosed osteoporosis. The inclusion criteria were no menstruation for more than 12 months and low bone mass or osteoporosis as defined by DXA. Glucose was calculated using a Hitachi 917 auto-analyzer. Insulin was determined using an enzyme-linked immunosorbent assay (EIA). Insulin resistance was estimated using a homeostasis model assessment of insulin resistance (HOMA-IR). DXA, 3D-DXA, and TBS were thus collected. Moreover, we examined bone parameters according to quartile of insulin, hemoglobin A1C (HbA1c), and HOMA-IR. Results: In this study, we included 381 postmenopausal women. Women located in quartile 4 (Q4) of HOMA-IR had higher values of volumetric bone mineral density (vBMD) but not TBS. The increase was higher in the trabecular compartment (16.4%) than in the cortical compartment (6.4%). Similar results were obtained for insulin. Analysis of the quartiles by HbA1c showed no differences in densitometry values, however women in Q4 had lower levels of TBS. After adjusting for BMI, statistical significance was maintained for TBS, insulin, HOMA-IR, and HbA1c. Conclusions: In non-diabetic postmenopausal women there was a direct relationship between insulin resistance and vBMD, whose effect is directly related to greater weight. TBS had an inverse relationship with HbA1c, insulin, and insulin resistance unrelated to weight. This might be explained by the formation of advanced glycosylation products (AGEs) in the bone matrix, which reduces bone deformation capacity and resistance, as well as increases fragility.
PB MDPI
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58971
UL https://uvadoc.uva.es/handle/10324/58971
LA eng
NO Journal Clinical Medicine, 2020, vol.9, n.6, 1732
NO Producción Científica
DS UVaDOC
RD 25-abr-2024