RT info:eu-repo/semantics/article
T1 Immune system disorders, cancer and viral infections: A new treatment opportunity for the immune checkpoint inhibitors
A1 Olivares Hernández, Alejandro
A1 Figuero Pérez, Luis
A1 Miramontes González, José Pablo
A1 López Gutiérrez, Álvaro
A1 González Sarmiento, Rogelio
A1 Cruz Hernández, Juan Jesús
A1 Fonseca Sánchez, Emilio
K1 Medicina
K1 Medicina Interna
K1 Cancer Research
K1 Viral infections
K1 Immunotherapy
K1 Immune checkpoint inhibitors
K1 Solid tumours
K1 Infecciones virales
K1 Inmunoterapia
K1 Inhibidores de puntos de control inmunitarios
K1 Tumores sólidos
K1 3205 Medicina Interna
AB The relationship between viral infections and cancer is well known and has been established for decades. Multiple tumours are generated from alterations secondary to viral infections 2 resulting from a dysregulation of the immune system in many cases. Certain causal relationships, such as that between the Epstein–Barr virus (EBV) in nasopharyngeal cancer or hepatitis C and B viruses in hepatocarcinoma, have been clearly established, and their implications for the prognosis and treatment of solid tumours are currently unknown. Multiple studies have evaluated the role that these infections may have in the treatment of solid tumours using immunotherapy. A possible relationship between viral infections and an increased response to immune checkpoint inhibitors (ICIs) has been established at a theoretical level in solid neoplasms, such as EBV-positive cavum cancer and human papillomavirus (HPV)-positive and oropharyngeal cancer. These could yield a greater response associated with the activation of the immune system secondary to viral infection, the consequence of which is an increase in survival in these patients. That is why the objective of this review is to assess the different studies or clinical trials carried out in patients with solid tumours secondary to viral infections and their relationship to the response to ICIs.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59087
UL https://uvadoc.uva.es/handle/10324/59087
LA eng
NO Life, 2021, vol. 11, n. 12, 1400
NO Producción Científica
DS UVaDOC
RD 16-jul-2024