RT info:eu-repo/semantics/article
T1 L-citrulline supplementation and exercise in the management of sarcopenia
A1 Caballero García, Alberto
A1 Pascual Fernández, Jorge
A1 Noriega González, David César
A1 Bello Gutierrez, Hugo José
A1 Pons Biescas, Antoni
A1 Roche Collado, Enrique
A1 Córdova Martínez, Alfredo
K1 Fisiología
K1 Geriatrics
K1 Envejecimiento
K1 Aging
K1 Muscle wasting
K1 Physical activity
K1 Sarcopenia
K1 Envejecimiento
K1 Pérdida muscular
K1 Actividad física
K1 2410.02 Anatomía Humana
K1 2411.10 Fisiología del Músculo
AB Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species. Therefore, supplements that can work as a vasodilators and control oxidative stress, might be beneficial for active elders. In this context, we have tested citrulline supplementation in a group of 44 participants aged from 60–73 years that followed a physical activity program adapted to their age and capacities. Volunteers were divided in two groups: placebo (n = 22) and citrullline supplemented (n = 22). Different physical tests and blood extractions were performed at the beginning and at the end of intervention (six weeks). Strength and endurance showed a tendency to increase in the citrulline supplemented group, with no significant differences respect to placebo. However, walking speed in the citrulline supplemented group improved significantly compared to placebo. Markers of muscle damage as well as circulating levels of testosterone, cortisol and vitamin D showed no significant changes, but a tendency to improve at the end of intervention in the supplemented group compared to placebo. Additional studies are necessary to confirm the effect of citrulline supplementation in sarcopenia delay.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59208
UL https://uvadoc.uva.es/handle/10324/59208
LA eng
NO Nutrients 2021, vol.13, n. 9, 3133
NO Producción Científica
DS UVaDOC
RD 18-nov-2024