RT info:eu-repo/semantics/article
T1 Goals and challenges of stem cell-based therapy for corneal blindness due to limbal deficiency
A1 Calonge, Margarita
A1 Nieto Miguel, Teresa
A1 De La Mata Sampedro, Ana
A1 Galindo de la Rosa, Sara
A1 Herreras Cantalapiedra, José María
A1 López Paniagua, Marina
K1 Medicina regenerativa
K1 Ophthalmology
K1 Células madre
K1 Blindness
K1 Cell therapy
K1 Limbal niche
K1 Ceguera
K1 Terapia celular
K1 Nicho limbal
K1 3201.09 Oftalmología
AB Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure occurs due to malfunction or destruction of the limbal stem cell niche, upon which the superficial cornea depends for homeostatic maintenance and wound healing. Failure of the limbal niche is referred to as limbal stem cell deficiency. As the corneal epithelial stem cell niche is easily accessible, limbal stem cell-based therapy and regenerative medicine applied to the ocular surface are among the most highly advanced forms of this novel approach to disease therapy. However, the challenges are still great, including the development of cell-based products and understanding how they work in the patient’s eye. Advances are being made at the molecular, cellular, and tissue levels to alter disease processes and to reduce or eliminate blindness. Efforts must be coordinated from the most basic research to the most clinically oriented projects so that cell-based therapies can become an integrated part of the therapeutic armamentarium to fight corneal blindness. We undoubtedly are progressing along the right path because cell-based therapy for eye diseases is one of the most successful examples of global regenerative medicine.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59238
UL https://uvadoc.uva.es/handle/10324/59238
LA eng
NO Pharmaceutics, 2021, vol. 13, n. 9, 1483
NO Producción Científica
DS UVaDOC
RD 15-ene-2025