RT info:eu-repo/semantics/article
T1 Vitamin D, its role in recovery after muscular damage following exercise
A1 Caballero García, Alberto
A1 Córdova Martínez, Alfredo
A1 Vicente Salar, Néstor
A1 Roche Collado, Enrique
A1 Pérez Valdecantos, Daniel
K1 Exercice
K1 Sports
K1 Ejercicio físico
K1 Immunology
K1 Inflammation
K1 Vitamin D
K1 2412 Inmunología
AB Aside from its role in bone metabolism, vitamin D is a key immunomodulatory micronutrient. The active form of vitamin D (1,25(OH)D) seems to modulate the innate immune system through different mechanisms. The vitamin is involved in the differentiation of monocytes into macrophages, increasing the phagocytic and chemotactic functions of these cells. At the same time, vitamin D enables efferocytosis and prevents immunopathology. In addition, vitamin D is involved in other processes related to immune function, such as inflammation. Regarding muscle tissue, vitamin D plays an active role in muscle inflammatory response, protein synthesis, and regulation of skeletal muscle function. Two mechanisms have been proposed: A direct role of 1,25(OH)D binding to vitamin D receptors (VDRs) in muscle cells and the modulation of calcium transport in the sarcoplasmic reticulum. This second mechanism needs additional investigation. In conclusion, vitamin D seems to be effective in cases of deficiency and/or if there is a great muscular commitment, such as in high intensity exercises.
PB MDPI
SN 2072-6643
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59453
UL https://uvadoc.uva.es/handle/10324/59453
LA eng
NO Nutrients 2021, Vol. 13, Nº. 7, 2336
NO Producción Científica
DS UVaDOC
RD 08-ago-2024